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Cadherin-16 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70594Amount:
100ulMolecular Weight:
89923DaApplications:
WB;IHC-p;IF/ICC;ELISAReactivity:
Human;Rat;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CDH16. AA range:780-829Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of A549 cells using Cadherin-16 Polyclonal Antibody diluted at 1:1000
Gene Name:
CDH16Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Cadherin-16Human Gene Id:
1014Human Swiss Prot No:
O75309Mouse Swiss Prot No:
O88338Specificity:
Cadherin-16 Polyclonal Antibody detects endogenous levels of Cadherin-16 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CDH16; Cadherin-16; Kidney-specific cadherin; Ksp-cadherinObserved Band(KD):
90Background:
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011],Function:
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 6 cadherin domains.,tissue specificity:Kidney specific.,Subcellular Location:
Cell membrane ; Single-pass type I membrane protein .Expression:
Kidney specific.
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