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C1QBP Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70564

  • Amount:

    100ul

  • Molecular Weight:

    31362Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human C1QBP. AA range:61-110

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using C1QBP Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    C1QBP

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Complement component 1 Q subcomponent-binding protein mitochondrial

  • Human Gene Id:

    708

  • Human Swiss Prot No:

    Q07021

  • Mouse Swiss Prot No:

    O35658

  • Rat Gene Id:

    29681

  • Rat Swiss Prot No:

    O35796

  • Specificity:

    C1QBP Polyclonal Antibody detects endogenous levels of C1QBP protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    C1QBP; GC1QBP; HABP1; SF2P32; Complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33

  • Observed Band(KD):

    32

  • Background:

    The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008],

  • Function:

    caution:Was originally (PubMed:1830244 and PubMed:8262387) thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.,function:Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.,similarity:Belongs to the MAM33 family.,subunit:Interacts with Rubella virus capsid protein.,

  • Subcellular Location:

    Mitochondrion matrix . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Extracellular side. Secreted. Cytoplasm . Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). .

  • Expression:

    Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.

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