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C1INH Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70561

  • Amount:

    100ul

  • Molecular Weight:

    55154Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SERPING1. AA range:342-391

  • Source:

    Polyclonal, Rabbit,IgG

  • Western blot analysis of SERPING1 Antibody. The lane on the right is blocked with the SERPING1 peptide.

  • Gene Name:

    SERPING1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Plasma protease C1 inhibitor

  • Human Gene Id:

    710

  • Human Swiss Prot No:

    P05155

  • Mouse Swiss Prot No:

    P97290

  • Specificity:

    C1INH Polyclonal Antibody detects endogenous levels of C1INH protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SERPING1; C1IN; C1NH; Plasma protease C1 inhibitor; C1 Inh; C1Inh; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1

  • Observed Band(KD):

    55

  • Background:

    This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.,function:Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagul

  • Subcellular Location:

    Secreted.

  • Expression:

    Blood,Brain,Foreskin,Heart,Liver,Plasma,Uterus,

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Catalog Number

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C1INH Polyclonal Antibody | EnoGene Biotech Co. Ltd