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BST-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70538Amount:
100ulMolecular Weight:
35724DaApplications:
WB;ELISAReactivity:
Human;Mouse;Rat;MonkeyPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using BST-1 Polyclonal Antibody
Gene Name:
BST1Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.Protein Name:
ADP-ribosyl cyclase 2Human Gene Id:
683Human Swiss Prot No:
Q10588Mouse Gene Id:
12182Mouse Swiss Prot No:
Q64277Rat Gene Id:
81506Rat Swiss Prot No:
Q63072Specificity:
BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157Observed Band(KD):
34Background:
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],Function:
catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.Expression:
Widely expressed.
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