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BRMS-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70527Amount:
100ulMolecular Weight:
28461DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human BRMS1. AA range:21-70Source:
Polyclonal, Rabbit,IgG
- Western blot analysis of lysates from 293 cells, using BRMS1 Antibody. The lane on the right is blocked with the synthesized peptide.
Gene Name:
BRMS1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Breast cancer metastasis-suppressor 1Human Gene Id:
25855Human Swiss Prot No:
Q9HCU9Mouse Gene Id:
107392Mouse Swiss Prot No:
Q99N20Rat Gene Id:
1.00912e+008Rat Swiss Prot No:
Q5M7T3Specificity:
BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
BRMS1; Breast cancer metastasis-suppressor 1Observed Band(KD):
28Background:
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],Function:
function:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,Subcellular Location:
Nucleus. Cytoplasm. Predominantly nuclear.Expression:
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
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