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BRCAA1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70521

  • Amount:

    100ul

  • Molecular Weight:

    147809DaObserved Band:148KD

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using BRCAA1 Polyclonal Antibody

  • Gene Name:

    ARID4B

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    AT-rich interactive domain-containing protein 4B

  • Human Gene Id:

    51742

  • Human Swiss Prot No:

    Q4LE39

  • Mouse Gene Id:

    94246

  • Mouse Swiss Prot No:

    A2CG63

  • Rat Gene Id:

    84481

  • Rat Swiss Prot No:

    Q9JKB5

  • Specificity:

    BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ARID4B; BRCAA1; RBBP1L1; RBP1L1; SAP180; AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Hi

  • Background:

    This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],

  • Function:

    domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.,

  • Subcellular Location:

    Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. .

  • Expression:

    Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.

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Catalog Number

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