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BMP-7 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70503

  • Amount:

    100ul

  • Molecular Weight:

    49313DaObserved Band:55KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BMP-7. AA range:124-173

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using BMP-7 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    BMP7

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Bone morphogenetic protein 7

  • Human Gene Id:

    655

  • Human Swiss Prot No:

    P18075

  • Mouse Gene Id:

    12162

  • Mouse Swiss Prot No:

    P23359

  • Specificity:

    BMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    BMP7; OP1; Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; Eptotermin alfa

  • Background:

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016],

  • Function:

    function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,

  • Subcellular Location:

    Secreted.

  • Expression:

    Expressed in the kidney and bladder. Lower levels seen in the brain.

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