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BMP-3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70499

  • Amount:

    100ul

  • Molecular Weight:

    53406DaObserved Band:53KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BMP-3. AA range:257-306

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using BMP-3 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    BMP3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Bone morphogenetic protein 3

  • Human Gene Id:

    651

  • Human Swiss Prot No:

    P12645

  • Mouse Gene Id:

    110075

  • Mouse Swiss Prot No:

    Q8BHE5

  • Rat Gene Id:

    25667

  • Rat Swiss Prot No:

    P49002

  • Specificity:

    BMP-3 Polyclonal Antibody detects endogenous levels of BMP-3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    BMP3; BMP3A; Bone morphogenetic protein 3; BMP-3; Bone morphogenetic protein 3A; BMP-3A; Osteogenin

  • Background:

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],

  • Function:

    function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,

  • Subcellular Location:

    Secreted.

  • Expression:

    Expressed in adult and fetal cartilage.

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Catalog Number

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