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BMP-2 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70498Amount:
100ulMolecular Weight:
44702DaObserved Band:44KDApplications:
IF/ICC;WB;IHC-p;ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized peptide derived from Bone morphogenetic protein 2 at AA range: 341-390Source:
Polyclonal, Rabbit,IgG
- Chen, Rui, et al. "Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux." Mediators of inflammation 2018 (2018).
Gene Name:
BMP2Dilution:
IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Bone morphogenetic protein 2Human Gene Id:
650Human Swiss Prot No:
P12643Mouse Gene Id:
12156Mouse Swiss Prot No:
P21274Rat Gene Id:
29373Rat Swiss Prot No:
P49001Specificity:
BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2ABackground:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],Function:
function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,Subcellular Location:
Secreted.Expression:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
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