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Blk Polyclonal Antibody
Datasheet
Catalog Number:
E20-70492Amount:
100ulMolecular Weight:
57706DaObserved Band:58KDApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human BLK. AA range:456-505Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Blk Polyclonal Antibody diluted at 1:500
Gene Name:
BLKDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Protein Name:
Tyrosine-protein kinase BlkHuman Gene Id:
640Human Swiss Prot No:
P51451Mouse Gene Id:
12143Mouse Swiss Prot No:
P16277Specificity:
Blk Polyclonal Antibody detects endogenous levels of Blk protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
BLK; Tyrosine-protein kinase Blk; B lymphocyte kinase; p55-BlkBackground:
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010],Function:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May function in a signal transduction pathway that is restricted to B-lymphoid cells.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,Subcellular Location:
Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). .Expression:
Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands
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