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BCSC-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70483Amount:
100ulMolecular Weight:
86489DaObserved Band:86KDApplications:
WB;ELISAReactivity:
Human;Rat;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using BCSC-1 Polyclonal Antibody
Gene Name:
VWA5ADilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
von Willebrand factor A domain-containing protein 5AHuman Gene Id:
4013Human Swiss Prot No:
O00534Mouse Swiss Prot No:
Q99KC8Specificity:
BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A proteinBackground:
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.Subcellular Location:
nucleus,nucleoplasm,Expression:
Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
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