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BCoR Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70480

  • Amount:

    100ul

  • Molecular Weight:

    192189DaObserved Band:192KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human BCOR. AA range:1231-1280

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using BCoR Polyclonal Antibody diluted at 1:500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit.

  • Gene Name:

    BCOR

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    BCL-6 corepressor

  • Human Gene Id:

    54880

  • Human Swiss Prot No:

    Q6W2J9

  • Mouse Gene Id:

    71458

  • Mouse Swiss Prot No:

    Q8CGN4

  • Specificity:

    BCoR Polyclonal Antibody detects endogenous levels of BCoR protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    BCOR; KIAA1575; BCL-6 corepressor; BCoR

  • Background:

    The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010],

  • Function:

    disease:Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or var

  • Subcellular Location:

    Nucleus .

  • Expression:

    Ubiquitously expressed.

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Catalog Number

  • Amount:100ul
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BCoR Polyclonal Antibody | EnoGene Biotech Co. Ltd