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ATP-citrate synthase Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70415

  • Amount:

    100ul

  • Molecular Weight:

    120839DaObserved Band:120KD

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase. AA range:420-469

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using ATP-citrate synthase Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ACLY

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    ATP-citrate synthase

  • Human Gene Id:

    47

  • Human Swiss Prot No:

    P53396

  • Mouse Gene Id:

    104112

  • Mouse Swiss Prot No:

    Q91V92

  • Rat Gene Id:

    24159

  • Rat Swiss Prot No:

    P16638

  • Specificity:

    ATP-citrate synthase Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

  • Background:

    ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],

  • Function:

    catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,

  • Subcellular Location:

    Cytoplasm, cytosol .

  • Expression:

    Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet,

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Catalog Number

  • Amount:100ul
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ATP-citrate synthase Polyclonal Antibody | EnoGene Biotech Co. Ltd