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ATF-6β Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70389

  • Amount:

    100ul

  • Molecular Weight:

    76709DaObserved Band:76KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using ATF-6β Polyclonal Antibody

  • Gene Name:

    ATF6B

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Cyclic AMP-dependent transcription factor ATF-6 beta

  • Human Gene Id:

    1388

  • Human Swiss Prot No:

    Q99941

  • Mouse Swiss Prot No:

    O35451

  • Specificity:

    ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ATF6B; CREBL1; G13; Cyclic AMP-dependent transcription factor ATF-6 beta; cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein;

  • Background:

    The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

  • Function:

    domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cy

  • Subcellular Location:

    Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .

  • Expression:

    Ubiquitous.

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Catalog Number

  • Amount:100ul
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ATF-6β Polyclonal Antibody | EnoGene Biotech Co. Ltd