ATF-2 Polyclonal Antibody

Name: ATF-2 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-70386
Price: 225 USD
Availability: InStock

E20-70386Cite ID: EN0050519Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight52277Da

Protein NameCyclic AMP-dependent transcription factor ATF-2

Human Gene Id1386

Human Swiss Prot NoP15336

Mouse Gene Id1.00048e+008

Mouse Swiss Prot NoP16951

Rat Gene Id81647

Rat Swiss Prot NoQ00969

SpecificityATF-2 Polyclonal Antibody detects endogenous levels of ATF-2 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro

Observed Band(KD)52

Functioncaution:It is uncertain whether Met-1 or Met-19 is the initiator.,function:Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.,PTM:Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds throu

Subcellular Locationnucleus,nucleoplasm,cytoplasm,mitochondrial outer membrane,site of double-strand break,

ExpressionEpithelium,Fetal brain,Myometrium,Pooled,Skin,Thymus,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human ATF2. AA range:38-87

Gene NameATF2

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.

Backgroundactivating transcription factor 2(ATF2) Homo sapiens This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-70386-Conjugate. Price: $485 / Size: 100μl.

E20-70386-FITC$485 / 100μlE20-70386-Biotin$485 / 100μlE20-70386-HRP$485 / 100μlE20-70386-AP$485 / 100μlE20-70386-AF350$485 / 100μlE20-70386-AF405M$485 / 100μlE20-70386-AF488$485 / 100μlE20-70386-AF514$485 / 100μlE20-70386-AF532$485 / 100μlE20-70386-AF555$485 / 100μlE20-70386-AF568$485 / 100μlE20-70386-AF405S$485 / 100μlE20-70386-AF405L$485 / 100μlE20-70386-AF546$485 / 100μlE20-70386-AF594$485 / 100μlE20-70386-AF610$485 / 100μlE20-70386-AF635$485 / 100μlE20-70386-AF647$485 / 100μlE20-70386-AF680$485 / 100μlE20-70386-AF700$485 / 100μlE20-70386-AF750$485 / 100μlE20-70386-AF790$485 / 100μlE20-70386-APC$485 / 100μlE20-70386-PE$485 / 100μlE20-70386-Cy3$485 / 100μlE20-70386-Cy5$485 / 100μlE20-70386-Cy5.5$485 / 100μlE20-70386-Cy7$485 / 100μlE20-70386-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.