Product Information
Molecular Weight113374DaObserved Band:113KD
Protein NameAtaxin-2-like protein
Human Gene Id11273
Human Swiss Prot NoQ8WWM7
Mouse Swiss Prot NoQ7TQH0
SpecificityAtaxin-2L Polyclonal Antibody detects endogenous levels of Ataxin-2L protein
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameATXN2L; A2D; A2LG; A2LP; A2RP; Ataxin-2-like protein; Ataxin-2 domain protein; Ataxin-2-related protein
FunctionPTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.,
Subcellular Locationcytoplasm,cell-cell adherens junction,cytoplasmic stress granule,membrane,integral component of membrane,nuclear speck,
ExpressionBrain,Colon carcinoma,Epithelium,Hippocampus,Lymph,Skin,T-cell,,
Backgroundataxin 2 like(ATXN2L) Homo sapiens This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],