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ASCL1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70367Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human ASCL1. AA range:109-158Source:
Polyclonal, RabbitGene Name:
ASCL1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of ASCL1 antibody in paraffin-embedded human brain tissue.
Background:
achaete-scute family bHLH transcription factor 1(ASCL1) Homo sapiens This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008],Protein Name:
Achaete-scute homolog 1Human Gene Id:
429Human Swiss Prot No:
P50553Mouse Gene Id:
17172Mouse Swiss Prot No:
Q02067Rat Gene Id:
64186Rat Swiss Prot No:
P19359Specificity:
ASCL1 Polyclonal Antibody detects endogenous levels of ASCL1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
ASCL1; ASH1; BHLHA46; HASH1; Achaete-scute homolog 1; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46MolecularWeight(Da):
25454Observed Band(KD):
25Function:
function:May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3').,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.,Subcellular Location:
nucleus,neuronal cell body,RNA polymerase II transcription factor complex,Expression:
Lung,Thyroid carcinoma,
- Western blot analysis of lysate from Jurkat cells, using ASCL1 antibody.
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Catalog Number
- Amount:100ul
- Price:225$
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