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Arylsulfatase A Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70347

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ARSA. AA range:251-300

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ARSA

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using ARSA Antibody. The picture on the right is blocked with the synthesized peptide.

  • Background:

    arylsulfatase A(ARSA) Homo sapiens The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010],

  • Protein Name:

    Arylsulfatase A

  • Human Gene Id:

    410

  • Human Swiss Prot No:

    P15289

  • Mouse Gene Id:

    11883

  • Mouse Swiss Prot No:

    P50428

  • Specificity:

    Arylsulfatase A Polyclonal Antibody detects endogenous levels of Arylsulfatase A protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ARSA; Arylsulfatase A; ASA; Cerebroside-sulfatase

  • MolecularWeight(Da):

    53588

  • Observed Band(KD):

    54

  • Function:

    catalytic activity:A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.,cofactor:Binds 1 magnesium ion per subunit.,disease:Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.,disease:Defects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tis

  • Subcellular Location:

    acrosomal vesicle,extracellular space,lysosome,endosome,endoplasmic reticulum lumen,integral component of membrane,extrinsic component of external side of plasma membrane,lysosomal lumen,extracellular exosome,

  • Expression:

    B-cell,Liver,Small intestine,Testis,

  • Western blot analysis of lysates from Jurkat and COLO cells, using ARSA Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Arylsulfatase A Polyclonal Antibody | EnoGene Biotech Co. Ltd