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ARHGEF10 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70321Amount:
100ulMolecular Weight:
151612DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;MonkeyPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using ARHGEF10 Polyclonal Antibody
Gene Name:
ARHGEF10Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Rho guanine nucleotide exchange factor 10Human Gene Id:
9639Human Swiss Prot No:
O15013Mouse Swiss Prot No:
Q8C033Specificity:
ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10Observed Band(KD):
152Background:
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],Function:
disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,Subcellular Location:
centrosome,cytosol,Expression:
Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,
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