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ARHGAP22 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70318Amount:
100ulSwiss-Prot No.:
Q7Z5H3/Q8BL80Molecular Weight:
76779，Observed Band : 77kdPrice:
225$Applications:
WB,IHC-p,IF(paraffin section),ELISAReactivity:
Human,Rat,MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human
RHG22. AA range:565-614Specificity/Sensitivity:
ARHGAP22 Polyclonal Antibody detects endogenous levels of ARHGAP22
protein.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
ARHGAP22Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA:
1/40000. Not yet tested in other applications.Background:
Rho GTPase activating protein 22(ARHGAP22) Homo sapiens This gene
encodes a member of the GTPase activating protein family which activates a
GTPase belonging to the RAS superfamily of small GTP-binding proteins. The
encoded protein is insulin-responsive, is dependent on the kinase Akt and
requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two
serine residues. The result of these interactions is regulation of cell motility.
Multiple transcript variants encoding different isoforms have been found for this
gene. [provided by RefSeq, Dec 2011]Gene ID:
58504Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
Rho GTPase-activating protein involved in the signal transductionPathway:
that regulates endothelial cell capillary tube formation duringangiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an
inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May
also play a role in transcription regulation via its interaction with VEZF1, by
regulating activity of the endothelin-1 (EDN1) promoter.,similarity:Contains 1 PH
domain.,similarity:Contains 1 Rho-GAP domain.,subcellular location:Mainly
cytoplasmic. Some fraction is nuclear.,subunit:Interacts with VEZF1
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