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AR Polyclonal Antibody
Datasheet
Catalog Number:
E20-70297Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Androgen Receptor. AA range:331-380Source:
Polyclonal, Rabbit
- Western blot analysis of lysates from K562 cells, treated with EGF 200ng/ml 5', using Androgen Receptor Antibody. The lane on the right is blocked with the synthesized peptide.
Gene Name:
ARDilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Background:
androgen receptor(AR) Homo sapiens The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoformProtein Name:
Androgen receptorHuman Gene Id:
367Human Swiss Prot No:
P10275Mouse Gene Id:
11835Mouse Swiss Prot No:
P19091Rat Gene Id:
24208Rat Swiss Prot No:
P15207Specificity:
AR Polyclonal Antibody detects endogenous levels of AR protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4MolecularWeight(Da):
98989Observed Band(KD):
85Function:
disease:Defects in AR are the cause of androgen insensitivity syndrome (AIS) [MIM:300068]; previously known as testicular feminization syndrome (TFM). AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.,disease:Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:312300]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.,disease:Defects in AR are the cause of spinal and bulbSubcellular Location:
nuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,integral component of membrane,protein complex,Expression:
Blood,Brain,Mammary carcinoma,Prostate,Testis,
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Catalog Number
- Amount:100ul
- Price:225$
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