APS Polyclonal Antibody

Name: APS Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-70285
Price: 225 USD
Availability: InStock

E20-70285Cite ID: EN0050418Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight67728 Da

Protein NameSH2B adapter protein 2

Human Gene Id10603

Human Swiss Prot NoO14492

Mouse Gene Id23921

Mouse Swiss Prot NoQ9JID9

Rat Gene Id114203

Rat Swiss Prot NoQ9Z200

SpecificityAPS Polyclonal Antibody detects endogenous levels of APS protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameSH2B2; APS; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS

Observed Band(KD)67

Functionfunction:Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.,PTM:Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.,similarity:Belongs to the SH2B adapter family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subcellular location:Cytoplasmic before PDGF stimulation. After PDG

Subcellular Locationstress fiber,ruffle,intracellular,cytoplasm,cytosol,actin filament,plasma membrane,

ExpressionB-cell,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from the Internal region of human APS.

Gene NameSH2B2

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

BackgroundSH2B adaptor protein 2(SH2B2) Homo sapiens The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-70285-Conjugate. Price: $485 / Size: 100μl.

E20-70285-FITC$485 / 100μlE20-70285-Biotin$485 / 100μlE20-70285-HRP$485 / 100μlE20-70285-AP$485 / 100μlE20-70285-AF350$485 / 100μlE20-70285-AF405M$485 / 100μlE20-70285-AF488$485 / 100μlE20-70285-AF514$485 / 100μlE20-70285-AF532$485 / 100μlE20-70285-AF555$485 / 100μlE20-70285-AF568$485 / 100μlE20-70285-AF405S$485 / 100μlE20-70285-AF405L$485 / 100μlE20-70285-AF546$485 / 100μlE20-70285-AF594$485 / 100μlE20-70285-AF610$485 / 100μlE20-70285-AF635$485 / 100μlE20-70285-AF647$485 / 100μlE20-70285-AF680$485 / 100μlE20-70285-AF700$485 / 100μlE20-70285-AF750$485 / 100μlE20-70285-AF790$485 / 100μlE20-70285-APC$485 / 100μlE20-70285-PE$485 / 100μlE20-70285-Cy3$485 / 100μlE20-70285-Cy5$485 / 100μlE20-70285-Cy5.5$485 / 100μlE20-70285-Cy7$485 / 100μlE20-70285-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.