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APLP2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70267

  • Amount:

    100ul

  • Molecular Weight:

    86956Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human APLP2. AA range:714-763

  • Source:

    Polyclonal, Rabbit,IgG

  • Gene Name:

    APLP2

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Western blot analysis of lysates from rat brain, using APLP2 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Background:

    This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

  • Protein Name:

    Amyloid-like protein 2

  • Human Gene Id:

    334

  • Human Swiss Prot No:

    Q06481

  • Mouse Gene Id:

    11804

  • Mouse Swiss Prot No:

    Q06335

  • Rat Swiss Prot No:

    P15943

  • Specificity:

    APLP2 Polyclonal Antibody detects endogenous levels of APLP2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP

  • Observed Band(KD):

    87

  • Function:

    alternative products:Additional isoforms seem to exist,function:May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.,PTM:The BPTI/Kunitz inhibitor domain is O-glycosylated.,similarity:Belongs to the APP family.,similarity:Contains 1 BPTI/Kunitz inhibitor domain.,subunit:Interacts with CPEB1.,tissue specificity:In placenta, brain, heart, lung, liver, kidney and endothelial tissues.,

  • Subcellular Location:

    Cell membrane ; Single-pass type I membrane protein . Nucleus .

  • Expression:

    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

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