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APC5 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70262

  • Amount:

    100ul

  • Molecular Weight:

    85077Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using APC5 Polyclonal Antibody

  • Gene Name:

    ANAPC5

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Anaphase-promoting complex subunit 5

  • Human Gene Id:

    51433

  • Human Swiss Prot No:

    Q9UJX4

  • Mouse Swiss Prot No:

    Q8BTZ4

  • Specificity:

    APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ANAPC5; APC5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5

  • Observed Band(KD):

    85

  • Background:

    This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],

  • Function:

    function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,

  • Subcellular Location:

    Nucleus . Cytoplasm, cytoskeleton, spindle .

  • Expression:

    Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga

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Catalog Number

  • Amount:100ul
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