World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
ALY Polyclonal Antibody
Human;Mouse;Rat
WB;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight26888Da
Protein NameTHO complex subunit 4
Human Gene Id10189
Human Swiss Prot NoQ86V81
Mouse Gene Id21681
Mouse Swiss Prot NoO08583
SpecificityALY Polyclonal Antibody detects endogenous levels of ALY protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameALYREF; ALY; BEF; THOC4; THO complex subunit 4; Tho4; Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF
Observed Band(KD)27
Functiondisease:Antibodies against THOC4 are found in sera of patients with systemic lupus erythematosus (SLE).,function:Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. May function as scaffold that mediates interactions between proteins and/or RNA. Integral part of the THO/TREX complex that is recruited to transcribed genes and travels with the RNA polymerase during elongation. Is part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway.,PTM:Arg-50 and Arg-204 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Phosphorylated upo
Subcellular LocationNucleus . Nucleus speckle . Cytoplasm . Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). .
ExpressionExpressed in a wide variety of cancer types.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human THOC4. AA range:121-170
Gene NameALYREF
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundThe protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-70208-Conjugate. Price: $485 / Size: 100μl.
E20-70208-FITC$485 / 100μlE20-70208-Biotin$485 / 100μlE20-70208-HRP$485 / 100μlE20-70208-AP$485 / 100μlE20-70208-AF350$485 / 100μlE20-70208-AF405M$485 / 100μlE20-70208-AF488$485 / 100μlE20-70208-AF514$485 / 100μlE20-70208-AF532$485 / 100μlE20-70208-AF555$485 / 100μlE20-70208-AF568$485 / 100μlE20-70208-AF405S$485 / 100μlE20-70208-AF405L$485 / 100μlE20-70208-AF546$485 / 100μlE20-70208-AF594$485 / 100μlE20-70208-AF610$485 / 100μlE20-70208-AF635$485 / 100μlE20-70208-AF647$485 / 100μlE20-70208-AF680$485 / 100μlE20-70208-AF700$485 / 100μlE20-70208-AF750$485 / 100μlE20-70208-AF790$485 / 100μlE20-70208-APC$485 / 100μlE20-70208-PE$485 / 100μlE20-70208-Cy3$485 / 100μlE20-70208-Cy5$485 / 100μlE20-70208-Cy5.5$485 / 100μlE20-70208-Cy7$485 / 100μlE20-70208-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits