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Aldolase A Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70191

  • Amount:

    100ul

  • Molecular Weight:

    39420Da

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ALDOA. AA range:1-50

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HT29 cells using Aldolase A Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ALDOA

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011],

  • Protein Name:

    Fructose-bisphosphate aldolase A

  • Human Gene Id:

    226

  • Human Swiss Prot No:

    P04075

  • Mouse Gene Id:

    11674

  • Mouse Swiss Prot No:

    P05064

  • Rat Gene Id:

    24189

  • Rat Swiss Prot No:

    P05065

  • Specificity:

    Aldolase A Polyclonal Antibody detects endogenous levels of Aldolase A protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ALDOA; ALDA; Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase

  • Observed Band(KD):

    39

  • Function:

    catalytic activity:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.,disease:Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive disorder associated with hereditary hemolytic anemia.,miscellaneous:In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.,similarity:Belongs to the class I fructose-bisphosphate aldolase family.,subunit:Homotetramer.,

  • Subcellular Location:

    Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, M line . In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). .

  • Expression:

    Brain,Cajal-Retzius cell,Cervix,Colon carcinoma,Epithelium,Eye,Feta

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Catalog Number

  • Amount:100ul
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Aldolase A Polyclonal Antibody | EnoGene Biotech Co. Ltd