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AK1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70156

  • Amount:

    100ul

  • Molecular Weight:

    67196(DA) Observed Band(KD)70

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MAP3K7. AA range:161-210

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MAP3K7

  • Dilution:

    IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Wu, Y., Ma, L., Cai, S. et al. RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation. Sig Transduct Target Ther 6, 167 (2021)

  • Protein Name:

    Mitogen-activated protein kinase kinase kinase 7

  • Human Gene Id:

    6885

  • Human Swiss Prot No:

    O43318

  • Mouse Gene Id:

    26409

  • Mouse Swiss Prot No:

    Q62073

  • Rat Gene Id:

    1.00911e+008

  • Rat Swiss Prot No:

    P0C8E4

  • Specificity:

    Tak1 Polyclonal Antibody detects endogenous levels of Tak1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1

  • Background:

    mitogen-activated protein kinase kinase kinase 7(MAP3K7) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity.,

  • Subcellular Location:

    nucleus,Ada2/Gcn5/Ada3 transcription activator complex,cytoplasm,cytosol,plasma membrane,IkappaB kinase complex,endosome membrane,

  • Expression:

    Epithelium,Lung,Platelet,Uterus,

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Catalog Number

  • Amount:100ul
  • Price:225$

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AK1 Polyclonal Antibody | EnoGene Biotech Co. Ltd