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AF-10 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70139Amount:
100ulMolecular Weight:
109026DaApplications:
WB;IHC-p;IF/ICC;ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human AF10. AA range:211-260Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using AF-10 Polyclonal Antibody diluted at 1:1000
Gene Name:
MLLT10Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Background:
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],Protein Name:
Protein AF-10Human Gene Id:
8028Human Swiss Prot No:
P55197Mouse Gene Id:
17354Mouse Swiss Prot No:
O54826Specificity:
AF-10 Polyclonal Antibody detects endogenous levels of AF-10 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 proteinObserved Band(KD):
109Function:
disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein.,disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Expressed abundantly in testis.,Subcellular Location:
Nucleus .Expression:
Expressed abundantly in testis.
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