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Cell Signal Transduction Research Antibodies
ADD1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight80955Da
Protein NameAlpha-adducin
Human Gene Id118
Human Swiss Prot NoP35611
Mouse Gene Id11518
Mouse Swiss Prot NoQ9QYC0
Rat Gene Id24170
Rat Swiss Prot NoQ63028
SpecificityADD1 Polyclonal Antibody detects endogenous levels of ADD1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameADD1; ADDA; Alpha-adducin; Erythrocyte adducin subunit alpha
Functionalternative products:Additional isoforms seem to exist,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.,tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.,
Subcellular Locationnucleus,nucleoplasm,cytosol,cytoskeleton,plasma membrane,cell-cell adherens junction,focal adhesion,F-actin capping protein complex,
ExpressionBrain cortex,Epithelium,Muscle,Platelet,Reticulocyte,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ADD1. AA range:411-460
Gene NameADD1
DilutionImmunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundadducin 1(ADD1) Homo sapiens Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-70124-Conjugate. Price: $485 / Size: 100μl.
E20-70124-FITC$485 / 100μlE20-70124-Biotin$485 / 100μlE20-70124-HRP$485 / 100μlE20-70124-AP$485 / 100μlE20-70124-AF350$485 / 100μlE20-70124-AF405M$485 / 100μlE20-70124-AF488$485 / 100μlE20-70124-AF514$485 / 100μlE20-70124-AF532$485 / 100μlE20-70124-AF555$485 / 100μlE20-70124-AF568$485 / 100μlE20-70124-AF405S$485 / 100μlE20-70124-AF405L$485 / 100μlE20-70124-AF546$485 / 100μlE20-70124-AF594$485 / 100μlE20-70124-AF610$485 / 100μlE20-70124-AF635$485 / 100μlE20-70124-AF647$485 / 100μlE20-70124-AF680$485 / 100μlE20-70124-AF700$485 / 100μlE20-70124-AF750$485 / 100μlE20-70124-AF790$485 / 100μlE20-70124-APC$485 / 100μlE20-70124-PE$485 / 100μlE20-70124-Cy3$485 / 100μlE20-70124-Cy5$485 / 100μlE20-70124-Cy5.5$485 / 100μlE20-70124-Cy7$485 / 100μlE20-70124-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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