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ADAR2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70119

  • Amount:

    100ul

  • Molecular Weight:

    80763Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ADARB1. AA range:481-530

  • Source:

    Polyclonal, Rabbit,IgG

  • Western blot analysis of lysates from HepG2 cells, using ADARB1 Antibody. The lane on the right is blocked with the synthesized peptide.

  • Gene Name:

    ADARB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Double-stranded RNA-specific editase 1

  • Human Gene Id:

    104

  • Human Swiss Prot No:

    P78563

  • Mouse Gene Id:

    110532

  • Mouse Swiss Prot No:

    Q91ZS8

  • Rat Gene Id:

    25367

  • Rat Swiss Prot No:

    P51400

  • Specificity:

    ADAR2 Polyclonal Antibody detects endogenous levels of ADAR2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ADARB1; ADAR2; DRADA2; RED1; Double-stranded RNA-specific editase 1; RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase

  • Observed Band(KD):

    80

  • Function:

    alternative products:Additional isoforms seem to exist,cofactor:Binds 1 inositol hexakisphosphate (IP6) per subunit.,function:Editing of the messenger RNAs for glutamate receptor (GluR) subunits by site-selective adenosine deamination. Edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently.,similarity:Contains 1 A to I editase domain.,similarity:Contains 2 DRBM (double-stranded RNA-binding) domains.,

  • Subcellular Location:

    Nucleus . Nucleus, nucleolus . Shuttles between nucleoli and the nucleoplasm. .; [Isoform 1]: Nucleus . Nucleus, nucleolus .; [Isoform 2]: Nucleus . Nucleus, nucleolus .

  • Expression:

    Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). ; [Isoform 5]: Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.

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Catalog Number

  • Amount:100ul
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ADAR2 Polyclonal Antibody | EnoGene Biotech Co. Ltd