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ADAMTS-1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70112

  • Amount:

    100ul

  • Molecular Weight:

    105358Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized peptide derived from ADAMTS-1 . at AA range: 160-240

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HUVEC cells using ADAMTS-1 Polyclonal Antibody

  • Gene Name:

    ADAMTS1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008],

  • Protein Name:

    A disintegrin and metalloproteinase with thrombospondin motifs 1

  • Human Gene Id:

    9510

  • Human Swiss Prot No:

    Q9UHI8

  • Mouse Swiss Prot No:

    P97857

  • Specificity:

    ADAMTS-1 Polyclonal Antibody detects endogenous levels of ADAMTS-1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ADAMTS1; KIAA1346; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; METH-1

  • Observed Band(KD):

    105

  • Function:

    catalytic activity:Cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain.,cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Conta

  • Subcellular Location:

    Secreted, extracellular space, extracellular matrix .

  • Expression:

    Brain,Colon endothel,Endothelial cell,Heart

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Catalog Number

  • Amount:100ul
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ADAMTS-1 Polyclonal Antibody | EnoGene Biotech Co. Ltd