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Cell Signal Transduction Research Antibodies
ACTR-IC Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight54871Da
Protein NameActivin receptor type-1C
Human Gene Id130399
Human Swiss Prot NoQ8NER5
Mouse Gene Id269275
Mouse Swiss Prot NoQ8K348
Rat Gene Id245921
Rat Swiss Prot NoP70539
SpecificityACTR-IC Polyclonal Antibody detects endogenous levels of ACTR-IC protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
Functioncatalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds the type 2 receptor protein ACVR2A.,tissue specificity:Present in pancreas, heart, colon, small intestine, ovary and
Subcellular Locationplasma membrane,activin receptor complex,
ExpressionBrain,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ACTR-1C. AA range:201-250
Gene NameACVR1C
DilutionImmunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundactivin A receptor type 1C(ACVR1C) Homo sapiens ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-70107-Conjugate. Price: $485 / Size: 100μl.
E20-70107-FITC$485 / 100μlE20-70107-Biotin$485 / 100μlE20-70107-HRP$485 / 100μlE20-70107-AP$485 / 100μlE20-70107-AF350$485 / 100μlE20-70107-AF405M$485 / 100μlE20-70107-AF488$485 / 100μlE20-70107-AF514$485 / 100μlE20-70107-AF532$485 / 100μlE20-70107-AF555$485 / 100μlE20-70107-AF568$485 / 100μlE20-70107-AF405S$485 / 100μlE20-70107-AF405L$485 / 100μlE20-70107-AF546$485 / 100μlE20-70107-AF594$485 / 100μlE20-70107-AF610$485 / 100μlE20-70107-AF635$485 / 100μlE20-70107-AF647$485 / 100μlE20-70107-AF680$485 / 100μlE20-70107-AF700$485 / 100μlE20-70107-AF750$485 / 100μlE20-70107-AF790$485 / 100μlE20-70107-APC$485 / 100μlE20-70107-PE$485 / 100μlE20-70107-Cy3$485 / 100μlE20-70107-Cy5$485 / 100μlE20-70107-Cy5.5$485 / 100μlE20-70107-Cy7$485 / 100μlE20-70107-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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