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ACOT8 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70089

  • Amount:

    100ul

  • Molecular Weight:

    Da:35914

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ACOT8. AA range:131-180

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HuvEc cells using ACOT8 Polyclonal Antibody

  • Gene Name:

    ACOT8

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010],

  • Protein Name:

    Acyl-coenzyme A thioesterase 8

  • Human Gene Id:

    10005

  • Human Swiss Prot No:

    O14734

  • Mouse Swiss Prot No:

    P58137

  • Specificity:

    ACOT8 Polyclonal Antibody detects endogenous levels of ACOT8 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ACOT8; ACTEIII; PTE1; PTE2; Acyl-coenzyme A thioesterase 8; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal lon

  • Observed Band(KD):

    36

  • Function:

    catalytic activity:Choloyl-CoA + H(2)O = cholate + CoA.,function:Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.,induction:Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs).,similarity:Belongs to the C/M/P thioester hydrolase family.,subunit:Interacts with HIV-1 Nef.,tissue specificity:Detect

  • Subcellular Location:

    Peroxisome matrix . Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. .

  • Expression:

    Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485)..

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Catalog Number

  • Amount:100ul
  • Price:225$

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ACOT8 Polyclonal Antibody | EnoGene Biotech Co. Ltd