You are here: EnoGene Home > Products > Cell Signal Transduction Research Antibodies > AChE Polyclonal Antibody

AChE Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70079

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ACHE. AA range:551-600

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ACHE

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of the lysates from HT-29 cells using ACHE antibody.

  • Background:

    acetylcholinesterase (Cartwright blood group)(ACHE) Homo sapiens Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively

  • Protein Name:

    Acetylcholinesterase

  • Human Gene Id:

    43

  • Human Swiss Prot No:

    P22303

  • Mouse Gene Id:

    11423

  • Mouse Swiss Prot No:

    P21836

  • Rat Gene Id:

    83817

  • Rat Swiss Prot No:

    P37136

  • Specificity:

    AChE Polyclonal Antibody detects endogenous levels of AChE protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ACHE; Acetylcholinesterase; AChE

  • MolecularWeight(Da):

    67796

  • Observed Band(KD):

    70

  • Function:

    catalytic activity:Acetylcholine + H(2)O = choline + acetate.,disease:Behaves as an amyloid-promoting factor to promote the formation of amyloid plaques in Alzheimer disease.,function:Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.,online information:Acetylcholinesterase entry,online information:Blood group antigen gene mutation database,polymorphism:ACHE is responsible for the Yt blood group system. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).,similarity:Belongs to the type-B carboxylesterase/lipase family.,subcellular location:Only observed in apoptotic nuclei.,subunit:Interacts with PRIMA1. The interaction with PRIMA1 is required to ancho

  • Subcellular Location:

    extracellular region,basal lamina,extracellular space,nucleus,Golgi apparatus,plasma membrane,cell surface,membrane,integral component of membrane,cell junction,anchored component of membrane,neuromuscula

  • Expression:

    Brain,Erythrocyte,

Add to Cart

Related Products

PTEN (Phospho-Ser380) Antibody
PTEN (Phospho-Ser380) Antibody Datasheet  

  • Catalog Number:

    E011009-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    IHC: 1:50~1:100

  • Swiss-Prot No.:

    P60484

  • Price:

    145$
  • Add to Cart
PTEN (Phospho-Ser380) Antibody
PTEN (Phospho-Ser380) Antibody Datasheet  

  • Catalog Number:

    E011009-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    IHC: 1:50~1:100

  • Swiss-Prot No.:

    P60484

  • Price:

    225$
  • Add to Cart
NFκB-p65 (Phospho-Ser468) Antibody
NFκB-p65 (Phospho-Ser468) Antibody Datasheet  

  • Catalog Number:

    E011013-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IF:1:100~1:200

  • Swiss-Prot No.:

    Q04206

  • Price:

    145$
  • Add to Cart
NFκB-p65 (Phospho-Ser468) Antibody
NFκB-p65 (Phospho-Ser468) Antibody Datasheet  

  • Catalog Number:

    E011013-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IF:1:100~1:200

  • Swiss-Prot No.:

    Q04206

  • Price:

    225$
  • Add to Cart
Rel (Phospho-Ser503) Antibody
Rel (Phospho-Ser503) Antibody Datasheet  

  • Catalog Number:

    E011020-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human

  • Applications:

    IF:1:100~1:200

  • Swiss-Prot No.:

    Q04864

  • Price:

    145$
  • Add to Cart

Catalog Number

  • Amount:100ul
  • Price:225$

Add to Cart

AbPromise

Contact us