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ACAT-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70071Amount:
100ulMolecular Weight:
45200DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human ACAT1. AA range:221-270Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of A549 cells using ACAT-1 Polyclonal Antibody
Gene Name:
ACAT1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Background:
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009],Protein Name:
Acetyl-CoA acetyltransferase mitochondrialHuman Gene Id:
38Human Swiss Prot No:
P24752Mouse Gene Id:
110446Mouse Swiss Prot No:
Q8QZT1Rat Gene Id:
25014Rat Swiss Prot No:
P17764Specificity:
ACAT-1 Polyclonal Antibody detects endogenous levels of ACAT-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
ACAT1; ACAT; MAT; Acetyl-CoA acetyltransferase; mitochondrial; Acetoacetyl-CoA thiolase; T2Observed Band(KD):
45Function:
catalytic activity:2 acetyl-CoA = CoA + acetoacetyl-CoA.,disease:Defects in ACAT1 are a cause of 3-ketothiolase deficiency (3KTD) [MIM:203750]; also known as alpha-methylacetoaceticaciduria. 3KTD is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype.,enzyme regulation:Activated by potassium ions, but not sodium ions.,function:Plays a major role in ketone body metabolism.,similarity:Belongs to the thiolase family.,subunit:Homotetramer.,Subcellular Location:
Mitochondrion .Expression:
Adipocyte,Brain,Fetal brain cortex,
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