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ABCB7 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70046

  • Amount:

    100ul

  • Molecular Weight:

    82641Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ABCB7. AA range:691-740

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using ABCB7 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ABCB7

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms hav

  • Protein Name:

    ATP-binding cassette sub-family B member 7 mitochondrial

  • Human Gene Id:

    22

  • Human Swiss Prot No:

    O75027

  • Mouse Swiss Prot No:

    Q61102

  • Specificity:

    ABCB7 Polyclonal Antibody detects endogenous levels of ABCB7 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ABCB7; ABC7; ATP-binding cassette sub-family B member 7; mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein

  • Observed Band(KD):

    83

  • Function:

    disease:Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.,function:Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.,similarity:Belongs to the ABC transporter family. Heavy Metal importer (TC 3.A.1.210) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,

  • Subcellular Location:

    Mitochondrion inner membrane ; Multi-pass membrane protein .

  • Expression:

    Human esophagus tumor,Muscle,Placenta,Umbilical cord blood,

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Catalog Number

  • Amount:100ul
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ABCB7 Polyclonal Antibody | EnoGene Biotech Co. Ltd