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Cleaved-Aggrecan (D369) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70042

  • Amount:

    100ul

  • Reactivity:

    Human,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Aggrecan. AA range:320-369

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ACAN

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Aggrecan (Cleaved-Asp369) Antibody. The picture on the right is blocked with the synthesized peptide

  • Protein Name:

    Aggrecan core protein

  • Human Gene Id:

    176

  • Human Swiss Prot No:

    P16112

  • Specificity:

    Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ACAN; AGC1; CSPG1; MSK16; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1MolecularWeight:250193Da

  • Observed Band(KD):

    44

  • Background:

    aggrecan(ACAN) Homo sapiens This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

  • Function:

    alternative products:Additional isoforms seem to exist,developmental stage:Expression was detected in chondrocytes throughout the developing skeleton.,disease:Defects in ACAN are thecause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphysealdysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.,domain:Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan,while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.,function:This proteoglyc

  • Subcellular Location:

    extracellular region,proteinaceous extracellular matrix,basement membrane,Golgi lumen,extracellular matrix,lysosomal lumen

  • Western blot analysis of lysates from Jurkat cells,treated with Etoposide 25uM 60', using Aggrecan(Cleaved-Asp369) Antibody. The lane on the rig is blocked with the synthesized peptide

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