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AASD-PPT Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70040

  • Amount:

    100ul

  • Molecular Weight:

    35776Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using AASD-PPT Polyclonal Antibody

  • Gene Name:

    AASDHPPT

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],

  • Protein Name:

    L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

  • Human Gene Id:

    60496

  • Human Swiss Prot No:

    Q9NRN7

  • Mouse Gene Id:

    67618

  • Mouse Swiss Prot No:

    Q9CQF6

  • Rat Gene Id:

    300328

  • Rat Swiss Prot No:

    B2RYJ4

  • Specificity:

    AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    AASDHPPT; CGI-80; HAH-P; HSPC223; x0005; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 4'-phosphopantetheinyl transferase; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; AASD-PPT;

  • Observed Band(KD):

    36

  • Function:

    catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.,

  • Subcellular Location:

    Cytoplasm, cytosol .

  • Expression:

    Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.

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