Product Information
Molecular Weight130615Da
Protein NameAdenylate cyclase type 5/6
Human Gene Id112/111
Human Swiss Prot NoO43306/O95622
Mouse Gene Id11512/224129
Rat Gene Id64532
Rat Swiss Prot NoQ03343/Q04400
SpecificityA Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase; ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V;
Functioncatalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:Membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,
Subcellular Locationintracellular,plasma membrane,cilium,membrane,integral component of membrane,intrinsic component of plasma membrane,
ExpressionBrain,Cardiac muscle,Epithelium,Eye,Platelet,Thyroid,
Backgroundadenylate cyclase 6(ADCY6) Homo sapiens This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015],