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A Cyclase V/VI Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70032

  • Amount:

    100ul

  • Molecular Weight:

    130615Da

  • Applications:

    IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ADCY5/6. AA range:931-980

  • Source:

    Polyclonal, Rabbit,IgG

  • Immunofluorescence analysis of HeLa cells, using ADCY5/6 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Gene Name:

    ADCY5/ADCY6

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015],

  • Protein Name:

    Adenylate cyclase type 5/6

  • Human Gene Id:

    112/111

  • Human Swiss Prot No:

    O43306/O95622

  • Mouse Gene Id:

    11512/224129

  • Rat Gene Id:

    64532

  • Rat Swiss Prot No:

    Q03343/Q04400

  • Specificity:

    A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase; ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V;

  • Function:

    catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:Membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

  • Subcellular Location:

    Cell membrane ; Multi-pass membrane protein . Cell projection, cilium . Cell projection, stereocilium .

  • Expression:

    Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539).

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Catalog Number

  • Amount:100ul
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A Cyclase V/VI Polyclonal Antibody | EnoGene Biotech Co. Ltd