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Mcl-1 (phospho Ser159) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61190

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MCL1 around the phosphorylation site of Ser159. AA range:125-174

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MCL1

  • Dilution:

    Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Western blot analysis of K562 using p-Mcl-1 (S159) antibody.

  • Background:

    BCL2 family apoptosis regulator(MCL1) Homo sapiens This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010],

  • Protein Name:

    Induced myeloid leukemia cell differentiation protein Mcl-1

  • Human Gene Id:

    4170

  • Human Swiss Prot No:

    Q07820

  • Mouse Gene Id:

    17210

  • Mouse Swiss Prot No:

    P97287

  • Specificity:

    Phospho-Mcl-1 (S159) Polyclonal Antibody detects endogenous levels of Mcl-1 protein only when phosphorylated at S159.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT

  • MolecularWeight(Da):

    37337

  • Observed Band(KD):

    39

  • Function:

    function:Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.,induction:Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat-shock induced differentiation. Expression increases early during retinoic acid-induced differentiation.,PTM:Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.,PTM:Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.,PTM:Rapidly degraded in the abs

  • Subcellular Location:

    nucleus,nucleoplasm,cytoplasm,mitochondrion,mitochondrial outer membrane,mitochondrial matrix,cytosol,membrane,integral component of membrane,myosin complex,Bcl-2 family protein complex,

  • Expression:

    Ewing sarcoma,Mammary gland,Myeloid leukemia cell,Neuroblastoma,Placenta,Th

  • Immunofluorescence analysis of A549 cells, using MCL1 (Phospho-Ser159) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Mcl-1 (phospho Ser159) Polyclonal Antibody | EnoGene Biotech Co. Ltd