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Rb (phospho Ser249) Polyclonal Antibody
Datasheet
Catalog Number:
E20-61184Amount:
100ulSwiss-Prot No.:
P06400/P13405/P33568Molecular Weight:
106159Price:
225$Applications:
IF/ICC,ELISAReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogenImmunogen:
The antiserum was produced against synthesized peptide derived from human
Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270Specificity/Sensitivity:
Phospho-Rb (S249) Polyclonal Antibody detects endogenous levels of Rb
protein only when phosphorylated at S249.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
RB1Dilution:
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other
- Immunofluorescence analysis of HeLa cells, using Retinoblastoma (Phospho-Ser249) Antibody. The picture on the right is blocked with the phospho peptide.
Background:
RB transcriptional corepressor 1(RB1) Homo sapiens The protein encoded by
this gene is a negative regulator of the cell cycle and was the first tumor
suppressor gene found. The encoded protein also stabilizes constitutive
heterochromatin to maintain the overall chromatin structure. The active,
hypophosphorylated form of the protein binds transcription factor E2F1. Defects
in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer,
and osteogenic sarcoma. [provided by RefSeq, Jul 2008]Gene ID:
5925/19645/24708Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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