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Kv2.1 (phospho Ser567) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61156

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Kv2.1/KCNB1 around the phosphorylation site of Ser567. AA range:533-582

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    KCNB1

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain, using Kv2.1/KCNB1 (Phospho-Ser567) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    potassium voltage-gated channel subfamily B member 1(KCNB1) Homo sapiens Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Potassium voltage-gated channel subfamily B member 1

  • Human Gene Id:

    3745

  • Human Swiss Prot No:

    Q14721

  • Mouse Gene Id:

    16500

  • Mouse Swiss Prot No:

    Q03717

  • Rat Gene Id:

    25736

  • Rat Swiss Prot No:

    P15387

  • Specificity:

    Phospho-Kv2.1 (S567) Polyclonal Antibody detects endogenous levels of Kv2.1 protein only when phosphorylated at S567.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KCNB1; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1

  • MolecularWeight(Da):

    95637

  • Function:

    domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.,PTM:Highly phosphorylated on serine residues in the C-terminal. Differential phosphorylation on a subset of serines allows graded activity-dependent regulation of channel gating. Phosphorylation on Ser-457, Ser-541, Ser-567, Ser-607, Ser-656 and Ser-720 as well as the N-terminal Ser-15 are all regulated by calcineurin-mediated dephosphorylation. Particularly, Ser-

  • Subcellular Location:

    intracellular,plasma membrane,voltage-gated potassium channel complex,lateral plasma membrane,cell junction,axon,dendrite,neuronal cell body membrane,sarcolemma,perikaryon,postsynaptic membrane,

  • Expression:

    Brain cortex,Lens epithelium,PCR rescued clones,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Kv2.1 (phospho Ser567) Polyclonal Antibody | EnoGene Biotech Co. Ltd