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DAPK1 (phospho Ser308) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61141

  • Amount:

    100ul

  • Reactivity:

    Human,Mouse

  • Purification:

    . The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DAPK1 around the phosphorylation site of Ser308. AA range:274-323

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    DAPK1

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

  • Protein Name:

    Death-associated protein kinase 1

  • Human Gene Id:

    1612

  • Human Swiss Prot No:

    P53355

  • Specificity:

    Phospho-DAPK1 (S308) Polyclonal Antibody detects endogenous levels of DAPK1 protein only when phosphorylated at S308.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DAPK1; DAPK; Death-associated protein kinase 1; DAP kinase 1MolecularWeight: 160286Da

  • Background:

    death associated protein kinase 1(DAPK1) Homo sapiens Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Negatively regulated by autophosphorylation on Ser-308.,function:Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.,induction:Up-regulated following treatment with interferon-gamma.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Colocalizes with the actin filament system.,

  • Subcellular Location:

    cytoplasm,plasma membrane,actin cytoskeleton,

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Catalog Number

  • Amount:100ul
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DAPK1 (phospho Ser308) Polyclonal Antibody | EnoGene Biotech Co. Ltd