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Rad51 (phospho Thr309) Polyclonal Antibody
Datasheet
Catalog Number:
E20-61106Amount:
100ulSwiss-Prot No.:
Q06609/Q08297Molecular Weight:
36966Price:
225$Applications:
WB,IHC-p,IF(paraffin section),ELISAReactivity:
Human,MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogenImmunogen:
The antiserum was produced against synthesized peptide derived from human
RAD51 around the phosphorylation site of Thr309. AA range:275-324Specificity/Sensitivity:
Phospho-Rad51 (T309) Polyclonal Antibody detects endogenous levels of
Rad51 protein only when phosphorylated at T309.Storage/Stability:
-20°C/1 yearSource:
RabbitBackground:
RAD51 recombinase(RAD51) Homo sapiens The protein encoded by this gene
is a member of the RAD51 protein family. RAD51 family members are highly
similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known
to be involved in the homologous recombination and repair of DNA. This protein
can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to
play roles in homologous pairing and strand transfer of DNA. This protein is also
found to interact with BRCA1 and BRCA2, which may be important for the cellular
response to DNA damage. BRCA2 is shown to regulate both the intracellular
localization and DNA-binding ability of this protein. Loss of these controls
following BRCA2 inactivation may be a key event leading to genomic instability
and tumorigenesis. Multiple transcript variants encoding different isoforms have
been found for this gene. [provided by RefSeq, Aug 2009]Gene ID:
5888/19361Pathway:
associated with the activation of homologous recombination and doublestrand break repair. Binds to single and double stranded DNA and exhibits DNAdependent ATPase activity. Underwinds duplex DNA and forms helicalnucleoprotein filaments.,PTM:Phosphorylated. Phosphorylation of Thr-309 byCHEK1/CHK1 may enhance association with chromatin at sites of DNA damageand promote DNA repair by homologous recombination.,similarity:Belongs to therecA family.,similarity:Belongs to the recA family. RAD51subfamily.,similarity:Contains 1 HhH domain.,subcellular location:Colocalizes withRAD51AP1 to multiple nuclear foci upon induction of DNAdamage.,subunit:Interacts with BRCA1, BRCA2 and either directly or indirectlywith p53. Interacts with XRCC3, RAD54L an
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