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Bax (phospho Ser184) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61081

  • Amount:

    100ul

  • Swiss-Prot No.:

    Q07812/ Q07813/Q63690

  • Molecular Weight:

    21184

  • Price:

    225$

  • Applications:

    IHC-p,IF(paraffin section),ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human
    Bax around the phosphorylation site of Ser184. AA range:143-192

  • Specificity/Sensitivity:

    Phospho-Bax (S184) Polyclonal Antibody detects endogenous levels of Bax
    protein only when phosphorylated at S184.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    BAX

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and NonPhosphopeptide (Phospho-right), using Bax (Phospho-Ser184) Antibody

  • Background:

    The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs
    to the BCL2 protein family. BCL2 family members form hetero- or homodimers
    and act as anti- or pro-apoptotic regulators that are involved in a wide variety of
    cellular activities. This protein forms a heterodimer with BCL2, and functions as
    an apoptotic activator. This protein is reported to interact with, and increase the
    opening of, the mitochondrial voltage-dependent anion channel (VDAC), which
    leads to the loss in membrane potential and the release of cytochrome c. The

  • Gene ID:

    581/12028

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Expression:

    of this gene is regulated by the tumor suppressor P53 and has beenshown to be involved in P53-mediated apoptosis. Multiple alternatively splicedtranscript variants, which encode different isoforms, have been reported for BAX

  • Function:

    disease:Defects in BAX are found in some cell lines from hematopoieticmalignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, andplasmacytoma.,domain:Intact BH3 motif is required by BIK, BID, BAK, BAD andBAX for their pro-apoptotic activity and for their interaction with anti-apoptoticmembers of the Bcl-2 family.,function:Accelerates programmed cell death bybinding to, and antagonizing the apoptosis repressor BCL2 or its adenovirushomolog E1B 19k protein. Induces the release of cytochrome c, activation ofCASP3, and thereby apoptosis.,similarity:Belongs to the Bcl-2 family.,subcellularlocation:Colocalizes with 14-3-3 proteins in the cytoplasm. Under stressconditions, redistributes to the mitochondrion membrane through the release fromJNK-phosphorylated 14-3-3 proteins.,subunit:Homodimer. Forms heterodimerswith BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1

  • Immunohistochemistry analysis of paraffin-embedded human
    brain, using Bax (Phospho-Ser184) Antibody. The picture on the
    right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Bax (phospho Ser184) Polyclonal Antibody | EnoGene Biotech Co. Ltd