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NOS2 (phospho Tyr151) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61067

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human iNOS around the phosphorylation site of Tyr151. AA range:117-166

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NOS2

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using iNOS (Phospho-Tyr151) Antibody

  • Background:

    nitric oxide synthase 2(NOS2) Homo sapiens Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Nitric oxide synthase inducible

  • Human Gene Id:

    4843

  • Human Swiss Prot No:

    P35228

  • Mouse Gene Id:

    18126

  • Mouse Swiss Prot No:

    P29477

  • Rat Gene Id:

    24599

  • Rat Swiss Prot No:

    Q06518

  • Specificity:

    Phospho-NOS2 (Y151) Polyclonal Antibody detects endogenous levels of NOS2 protein only when phosphorylated at Y151.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

  • MolecularWeight(Da):

    131117

  • Function:

    catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.,function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.,induction:By endotoxins and cytokines.,online information:Nitric oxide synthase entry,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subunit:Homodimer. Bin

  • Subcellular Location:

    intracellular,nucleus,cytoplasm,peroxisome,cytosol,cortical cytoskeleton,perinuclear region of cytoplasm,

  • Expression:

    Airway epithelium,Articular chondrocyte,Cardiac myocyte,Chondrocyte,Colon adenocarc

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using iNOS (Phospho-Tyr151) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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NOS2 (phospho Tyr151) Polyclonal Antibody | EnoGene Biotech Co. Ltd