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Ephrin-B1/2 (phospho Tyr329) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61066

  • Amount:

    100ul

  • Molecular Weight:

    36923Da

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Ephrin B1/B2 around the phosphorylation site of Tyr329. AA range:295-344

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    EFNB1/EFNB2

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Ephrin B1/B2 (Phospho-Tyr329) Antibody

  • Protein Name:

    Ephrin-B1/2

  • Human Gene Id:

    1947/1948

  • Human Swiss Prot No:

    P98172/P52799

  • Specificity:

    Phospho-Ephrin-B1/2 (Y329) Polyclonal Antibody detects endogenous levels of Ephrin-B1/2 protein only when phosphorylated at Y329.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EFNB1; EFL3; EPLG2; LERK2; Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; EFNB2; EPLG5; HTKL; LERK5; Ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L

  • Background:

    ephrin B1(EFNB1) Homo sapiens The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.,function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.,induction:By TNF-alpha.,PTM:Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.,similarity:Belongs to the ephrin family.,subunit:Interacts with GRIP1 and GRIP2.,tissue specificity:Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.,

  • Subcellular Location:

    nucleus,cytoplasm,plasma membrane,integral component of plasma membrane,membrane raft,synapse,extracellular exosome,

  • Expression:

    Eye,Fetal brain,Placenta,Skin,

  • Immunohistochemistry analysis of paraffin-embedded human brain, using Ephrin B1/B2 (Phospho-Tyr329) Antibody. The picture on the right is blocked with the phospho peptide.

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  • Amount:100ul
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