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EphA3/4/5 (phospho Tyr779/833) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61041

  • Amount:

    100ul

  • Molecular Weight:

    110131/109860/114784(DA) Observed Band(KD)110

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human EPHA3/4/5 around the phosphorylation site of Tyr779/833. AA range:746-795

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    EPHA3/EPHA4/EPHA5

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain, using EPHA3/4/5 (Phospho-Tyr779/833) Antibody. The picture on the right is blocked with the phospho peptide.

  • Protein Name:

    Ephrin type-A receptor 3/4/5

  • Human Gene Id:

    2042/2043

  • Human Swiss Prot No:

    P29320/P54764/P54756

  • Mouse Gene Id:

    13838/13839

  • Rat Gene Id:

    29210/79208

  • Rat Swiss Prot No:

    O08680/P54757

  • Specificity:

    Phospho-EphA3/4/5 (Y779/833) Polyclonal Antibody detects endogenous levels of EphA3/4/5 protein only when phosphorylated at Y779/833.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1; EPHA4; HEK8; SEK; TYRO1; Ephri

  • Background:

    EPH receptor A3(EPHA3) Homo sapiens This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,

  • Subcellular Location:

    extracellular region,early endosome,plasma membrane,integral component of plasma membrane,integral component of membrane,

  • Expression:

    Lung,Melanoma,Placenta,

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  • Amount:100ul
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