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Desmin (phospho Ser60) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-61022

  • Amount:

    100ul

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen..

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Desmin around the phosphorylation site of Ser60. AA range:26-75

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    DES

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using Desmin (Phospho-Ser60) Antibody. The picture on the right is blocked with the phospho peptide.

  • Protein Name:

    Desmin

  • Human Gene Id:

    1674

  • Human Swiss Prot No:

    P17661

  • Specificity:

    Phospho-Desmin (S60) Polyclonal Antibody detects endogenous levels of Desmin protein only when phosphorylated at S60.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DES; DesminMolecularWeight: 53536Da

  • Background:

    desmin(DES) Homo sapiens This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).,disease:Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400].

  • Subcellular Location:

    cytosol,intermediate filament,fascia adherens,intercalated disc,Z disc,neuromuscular junction,sarcolemma,intermediate filament cytoskeleton,extracellular exosome,

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Catalog Number

  • Amount:100ul
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Desmin (phospho Ser60) Polyclonal Antibody | EnoGene Biotech Co. Ltd